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In Summary: The oxidative phase of the pentose phosphate shunt can generate NADPH, without generating a net increase of ribose-phosphate by using the ribose-phosphate sugars formed as substrates for the non-oxidative phase, which converts them to fructose-6-phosphate and glyceraldehyde-3-phosphate that can then enter the glycolytic pathway

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Chronic Granulomatous Disease Because of the need for NADPH in phagocytic cells, by the NADPH oxidase (NOX) system, any defect in enzymes in this process can result in impaired killing of infectious organisms

Your doctor may suggest slowing down the dose escalation, temporarily reducing your Retatrutide dose, or pausing treatment until the symptoms clear